Brain-immune interactions and disease susceptibility
نویسندگان
چکیده
منابع مشابه
Brain-immune interactions in health and disease
Modern medicine cannot avoid the understanding of the fine-tuned communication between the many, seemingly distinct systems in the body. An excellent example of this is the challenge to understand the bi-directional communication between the brain and the immune system. Brain-immune interactions take place in different organs, involving a wide range of cells and mediators, coordinated through s...
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The integration between immune and neuroendocrine systems is crucial for maintaining homeostasis from invertebrates to humans. In the first, the phagocytic cell, i.e., the immunocyte, is the main actor, while in the latter, the principle player is the lymphocyte. Immunocytes are characterized by the presence of pro-opiomelanocortin (POMC) peptides, CRH, and other molecules that display a signif...
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Cytokines interact with the nervous system in numerous ways. These molecules are expressed within the central nervous system (CNS) 1 and play an important role in neuronal cell death and survival. In addition, peripheral cytokines released from immune cells during inflammation can stimulate a variety of physiological, neuroendocrine, and behavioral responses of the CNS, including fever, sleep, ...
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Neuro-immune interactions are widely manifested in animal physiology. Since immunity competes for energy with other physiological functions, it is subject to a circadian trade-off between other energy-demanding processes, such as neural activity, locomotion and thermoregulation. When immunity is challenged, this trade-off is tilted to an adaptive energy protecting and reallocation strategy that...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2005
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001643